ea0003p120 | Endocrine Tumours and Neoplasia | BES2002
Musat M
, Korbonits M
, Pyle M
, Gueorguiev M
, Powell M
, Dumitrache C
, Poiana C
, Grossman A
Disruption of the normal cell cycle is one of the most frequent alterations in tumour cells, contributing to uncontrolled cell proliferation during tumour development. The CDK inhibitor p27 plays a pivotal role in controlling cell proliferation during development and tumourigenesis, and has been implicated in tumorigenesis in rats. Previous studies have demonstrated changes in p27 protein expression, in human pituitary tumours,especially in corticotroph tumours, where p27 prot...